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Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke

1 illustrates the essential reactions and feedback mechanisms among ROS, GSH, GSSG, NADPH and G6P in the outer retina, which we focus on and model as a system of ordinary differential equations (ODEs), where all parameters are non-negative

49 MorisseS.ZaffagniniM.GaoX.-H.LemaireS

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MASP-1 and MASP-2 are associated with common collagen regions within MBL, ficolins, and collectins ( Figure 2B ), whereas MASP-3 activity is connected to the alternative CS pathway activation via the proteolytic cleavage of pro-Factor D (FD) to enzymatically active mature FD ( Figure 2C )